Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | CSF1R | P07333 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 5/20 | 0.38 |
| ▸ | FYN | P06241 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | BTK | Q06187 | 2/20 | 0.38 |
| ▸ | STK16 | O75716 | 1/20 | 0.38 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 7/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4319121 | 0.89 | AURKA (0.45) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL3153474 | 0.85 | AURKA (0.49) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL3143344 | 0.82 | AURKA (0.54) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL13932960 | 0.82 | AURKA (0.44) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL17627185 | 0.80 | AURKA (0.59) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL3148016 | 0.80 | AURKA (0.59) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL3138272 | 0.79 | AURKA (0.49) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL13666773 | 0.79 | AURKA (0.49) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL3144080 | 0.79 | AURKA (0.56) | AURKAAURKBCSF1RJAK3JAK2 | |
| SCHEMBL3146870 | 0.78 | AURKA (0.48) | AURKAAURKBCSF1RJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1511742-B1 | KINASE INHIBITORS | CYTOPIA RES PTY LTD (AU) | 2010-02-03 | — | — | EP | claimed |