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SCHEMBL31444695

SCHEMBL31444695

C[C@@H]1CN(c2ncc(Cl)c(Nc3ccc4c(c3)N(CCC(C)(C)O)C(=O)C4)n2)CC[C@H]1Nc1ccc2c(C3CCC(=O)NC3=O)nn(C)c2c1

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 18/20 0.44
▸ NCOR2 Q9Y618 5/20 0.44
▸ DDB1 Q16531 2/20 0.43
▸ CRBN Q96SW2 2/20 0.43
▸ ADRB3 P13945 1/20 0.42
▸ HTR1D P28221 1/20 0.42
▸ ADORA1 P30542 1/20 0.42
▸ OPRM1 P35372 1/20 0.42
▸ SLC6A3 Q01959 1/20 0.42
▸ TMEM97 Q5BJF2 1/20 0.42
▸ HRH3 Q9Y5N1 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26754415 1.00 BCL6 (0.44) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL26752227 0.92 DDB1 (0.50) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL31444723 0.92 DDB1 (0.50) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL30661507 0.90 DDB1 (0.43) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL26621698 0.90 DDB1 (0.43) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL26621683 0.90 DDB1 (0.43) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL30661518 0.90 DDB1 (0.43) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL26621678 0.90 DDB1 (0.43) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL30661595 0.90 DDB1 (0.43) BCL6NCOR2DDB1CRBNADRB3
SCHEMBL30661598 0.90 DDB1 (0.46) BCL6NCOR2DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096710-A1 MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 — — WO disclosed
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