SCHEMBL31444757

SCHEMBL31444757

O=C1CCC(N2Cc3cc(CCCl)ccc3C2=O)C(=O)N1

nearest known ligand 0.66

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 11/20 0.66
▸ GSPT1 P15170 2/20 0.58
▸ DDB1 Q16531 2/20 0.58
▸ CYP2C19 P33261 1/20 0.58
▸ KCNH2 Q12809 1/20 0.58
▸ IKZF3 Q9UKT9 1/20 0.57
▸ IKZF2 Q9UKS7 8/20 0.55
▸ IKZF1 Q13422 1/20 0.55
▸ CSNK1A1 P48729 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25234569 0.91 CRBN (0.69) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL31444586 0.90 CRBN (0.67) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL29188614 0.89 CRBN (0.66) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL31444715 0.89 CRBN (0.69) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL23657089 0.89 CRBN (0.66) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL31554762 0.89 CRBN (0.73) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL31444576 0.89 CRBN (0.73) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL25228921 0.87 CRBN (0.70) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL24421576 0.87 CRBN (0.64) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL22906957 0.87 CRBN (0.67) CRBNGSPT1DDB1CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025096710-A1 MODULATORS OF BCL6 AS LIGAND DIRECTED DEGRADERS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-05-08 — — WO disclosed
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