SCHEMBL31447660

SCHEMBL31447660

O=C1CCC(N2C(=O)c3ccc(N4CCC(CN5CCC(c6ccccn6)CC5)CC4)cc3C2=O)C(=O)N1

nearest known ligand 0.60

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 13/20 0.60
▸ AR P10275 3/20 0.55
▸ BTK Q06187 3/20 0.52
▸ PLK4 O00444 1/20 0.47
▸ CDK9 P50750 1/20 0.46
▸ DDB1 Q16531 5/20 0.46
▸ ALDH1A1 P00352 1/20 0.46
▸ CHRM2 P08172 1/20 0.46
▸ OPRM1 P35372 1/20 0.46
▸ IKZF3 Q9UKT9 1/20 0.46
▸ CYP1A2 P05177 1/20 0.46
▸ TSHR P16473 1/20 0.46
▸ TDP1 Q9NUW8 1/20 0.46
▸ EGFR P00533 2/20 0.45
▸ IRAK1 P51617 1/20 0.45
▸ IRAK4 Q9NWZ3 1/20 0.45
▸ IRAK3 Q9Y616 1/20 0.45
▸ ALK Q9UM73 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31447960 0.93 CRBN (0.57) CRBNARBTKPLK4DDB1
SCHEMBL31447942 0.88 CRBN (0.62) CRBNARBTKCDK9DDB1
SCHEMBL30160803 0.87 CRBN (0.65) CRBNARBTKDDB1ALDH1A1
SCHEMBL31447732 0.85 CRBN (0.80) CRBNARBTKCDK9DDB1
SCHEMBL24421652 0.84 CRBN (0.69) CRBNARBTKPLK4CDK9
SCHEMBL26969669 0.84 CRBN (0.69) CRBNARBTKPLK4CDK9
SCHEMBL30160860 0.84 CRBN (0.74) CRBNARBTKCDK9DDB1
SCHEMBL21983035 0.83 CRBN (0.70) CRBNARBTKCDK9DDB1
SCHEMBL31447711 0.83 CRBN (0.59) CRBNARBTKPLK4CDK9
SCHEMBL23860209 0.83 CRBN (0.66) CRBNARBTKPLK4CDK9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250041429-A1 COMPOUND HAVING BTK PROTEIN DEGRADATION ACTIVITY, AND MEDICAL USES THEREOF UBIX THERAPEUTICS, INC. (KR) 2025-02-06 — — US claimed
US-20250041429-A1 COMPOUND HAVING BTK PROTEIN DEGRADATION ACTIVITY, AND MEDICAL USES THEREOF UBIX THERAPEUTICS, INC. (KR) 2025-02-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250041429-A1 COMPOUND HAVING BTK PROTEIN DEGRADATION ACTIVITY, AND MEDICAL USES THEREOF BTK, LYN, SYK CRBN 324/4885AR 3571/4885BTK 1/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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