SCHEMBL31450665

COC(=O)N[C@@H](CC/C=C/C(=O)N(C)C)C(=O)Nc1cccn(Cc2nc3c(CC(C)C)nccc3n2C(=O)OC(C)(C)C)c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 1)

	gene	UniProt	supporting neighbours	confidence
▸	MAP4K1	Q92918	20/20	1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL23452731	1.00	MAP4K1 (1.00)	MAP4K1
SCHEMBL21684097	0.92	MAP4K1 (0.85)	MAP4K1
SCHEMBL21684092	0.92	MAP4K1 (0.85)	MAP4K1
SCHEMBL21684095	0.92	MAP4K1 (0.85)	MAP4K1
SCHEMBL21684464	0.90	MAP4K1 (0.82)	MAP4K1
SCHEMBL30203436	0.90	MAP4K1 (0.82)	MAP4K1
SCHEMBL21703154	0.90	MAP4K1 (0.82)	MAP4K1
SCHEMBL21684468	0.90	MAP4K1 (0.82)	MAP4K1
SCHEMBL21703155	0.89	MAP4K1 (0.80)	MAP4K1
SCHEMBL30203298	0.89	MAP4K1 (0.80)	MAP4K1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-4219460-B1	TRANSGLUTAMINASE 2 (TG2) INHIBITORS	SITARI PHARMA INC (US)	2025-02-26	—	—	EP	claimed