Sugi Predict

Sugi Predict / Compounds / SCHEMBL31450757

SCHEMBL31450757

SCHEMBL31450757

CC(C)(C)OC(=O)NCCCNc1ccc(S(=O)(=O)NC(=O)c2ccc(N3CCN(Cc4ccccc4-c4ccc(Cl)cc4)CC3)cc2Oc2cnc3[nH]ccc3c2)cc1S(=O)(=O)C(F)(F)F

nearest known ligand 0.72

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 11/20 0.66
▸ ADRA1D P25100 1/20 0.58
▸ DRD3 P35462 1/20 0.58
▸ SLC6A3 Q01959 1/20 0.58
▸ TMEM97 Q5BJF2 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26647748 1.00 BCL2 (0.66) BCL2ADRA1DDRD3SLC6A3TMEM97
SCHEMBL33532756 1.00 BCL2 (0.66) BCL2ADRA1DDRD3SLC6A3TMEM97
SCHEMBL31450809 0.94 BCL2 (0.68) BCL2ADRA1DDRD3SLC6A3TMEM97
SCHEMBL26648367 0.94 BCL2 (0.68) BCL2ADRA1DDRD3SLC6A3TMEM97
SCHEMBL31450911 0.92 BCL2 (0.65) BCL2
SCHEMBL31450985 0.92 BCL2 (0.68) BCL2ADRA1DDRD3SLC6A3TMEM97
SCHEMBL26648189 0.92 BCL2 (0.68) BCL2ADRA1DDRD3SLC6A3TMEM97
SCHEMBL26647886 0.92 BCL2 (0.67) BCL2
SCHEMBL31450815 0.92 BCL2 (0.67) BCL2
SCHEMBL26648376 0.90 BCL2 (0.66) BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4522154-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-03-19 — — EP disclosed
Send feedback