SCHEMBL31450984

SCHEMBL31450984

CC1(C)CCC(CN2CCN(c3ccc(C(=O)NS(=O)(=O)c4ccc(NC5CC(N6CCNCC6)C5)c(S(=O)(=O)C(F)(F)F)c4)c(Oc4cnc5[nH]ccc5c4)c3)CC2)=C(c2ccc(Cl)cc2)C1

nearest known ligand 0.88

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 19/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26648646 1.00 BCL2 (0.88) BCL2
SCHEMBL31450969 0.97 BCL2 (0.89) BCL2
SCHEMBL31450966 0.97 BCL2 (0.89) BCL2
SCHEMBL26647805 0.97 BCL2 (0.89) BCL2
SCHEMBL26648270 0.94 BCL2 (0.90) BCL2
SCHEMBL31450956 0.94 BCL2 (0.90) BCL2
SCHEMBL30314007 0.94 BCL2 (1.00) BCL2
SCHEMBL1809672 0.94 BCL2 (1.00) BCL2
SCHEMBL31450988 0.92 BCL2 (0.87) BCL2
SCHEMBL26647863 0.92 BCL2 (0.87) BCL2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4522154-A1 BCL-XL/BCL-2 DEGRADERS AND USES THEREOF Kymera Therapeutics, Inc. (US) 2025-03-19 — — EP disclosed
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