Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.61 |
| ▸ | THRB | P10828 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 6/20 | 0.58 |
| ▸ | PPARG | P37231 | 5/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31451577 | 0.93 | MAPT (0.70) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451567 | 0.92 | MAPT (0.60) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451486 | 0.89 | MAPT (0.57) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451341 | 0.88 | PPARG (0.50) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451534 | 0.86 | MAPT (0.70) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451514 | 0.85 | MAPT (0.69) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451417 | 0.85 | MAPT (0.69) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451573 | 0.83 | MAPT (0.66) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451706 | 0.81 | MAPT (0.71) | MAPTTHRBSMN1; SMN2TP53PPARG | |
| SCHEMBL31451632 | 0.81 | TP53 (0.57) | MAPTTHRBSMN1; SMN2TP53TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025054187-A1 | TGR5 ANTAGONISTS AND METHODS OF USE | Sanford Burnham Prebys Medical Discovery Institute (US) | 2025-03-13 | — | — | WO | disclosed |