Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.35 |
| ▸ | IDH1 | O75874 | 13/20 | 0.34 |
| ▸ | IDH2 | P48735 | 12/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31452094 | 0.81 | WEE1 (0.35) | WEE1IDH1IDH2 | |
| SCHEMBL18459488 | 0.76 | IDH1 (0.41) | WEE1FGFR4IDH1IDH2MEN1 | |
| SCHEMBL18459331 | 0.75 | FGFR4 (0.35) | FGFR4IDH1IDH2MEN1KMT2A | |
| SCHEMBL18459263 | 0.70 | IDH1 (0.40) | FGFR4IDH1IDH2MEN1KMT2A | |
| SCHEMBL31452027 | 0.65 | IDH1 (0.36) | IDH1IDH2 | |
| SCHEMBL22419389 | 0.62 | MEN1 (0.38) | FGFR4KDM4EMAPTNPSR1ALDH1A1 | |
| SCHEMBL18459827 | 0.61 | IDH1 (0.31) | IDH1IDH2 | |
| SCHEMBL19200206 | 0.61 | WEE1 (0.42) | WEE1FGFR4MEN1KMT2A | |
| SCHEMBL18425096 | 0.60 | MB (0.36) | FGFR4KDM4EMAPTMEN1KMT2A | |
| SCHEMBL31139435 | 0.60 | FGFR4 (0.48) | FGFR4KDM4EMAPTALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250049809-A1 | INHIBITORS OF MUTANT IDH1 AND IDH2 | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2025-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250049809-A1 | INHIBITORS OF MUTANT IDH1 AND IDH2 | IDH1, IDH2, IDH3A | WEE1 742/4885FGFR4 1678/4885IDH1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.