SCHEMBL31458473

SCHEMBL31458473

COc1cc(N2CCC3(CCN(C(=O)C(F)(F)F)CC3)CC2)c(-c2cnn(C)c2)cc1Nc1ncc(Br)c(Nc2ccc3nccnc3c2N(C)S(C)(=O)=O)n1

nearest known ligand 0.47

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EGFR P00533 20/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31458431 0.90 EGFR (0.49) EGFR
SCHEMBL25001403 0.87 EGFR (0.59) EGFR
SCHEMBL27091359 0.84 EGFR (0.62) EGFR
SCHEMBL29785229 0.84 EGFR (0.62) EGFR
SCHEMBL31458384 0.83 EGFR (0.53) EGFR
SCHEMBL31458490 0.82 EGFR (0.40) EGFR
SCHEMBL25001671 0.82 EGFR (0.57) EGFR
SCHEMBL29785342 0.80 EGFR (0.54) EGFR
SCHEMBL27091490 0.80 EGFR (0.54) EGFR
SCHEMBL25001799 0.80 EGFR (0.65) EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025067509-A1 EGFR DEGRADANT, AND PREPARATION METHOD AND USE THEREFOR 石药集团中奇制药技术(石家庄)有限公司 2025-04-03 — — WO disclosed
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