Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 13/20 | 0.70 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.61 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.61 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.61 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.57 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.57 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.52 |
| ▸ | ATR | Q13535 | 2/20 | 0.51 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.48 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.48 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3141223 | 0.85 | PIK3CA (0.75) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3142026 | 0.84 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3150226 | 0.84 | PIK3CA (0.74) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3146450 | 0.82 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3141708 | 0.81 | PIK3CA (0.70) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3142070 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3150795 | 0.80 | PIK3CA (0.68) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3150915 | 0.80 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3141782 | 0.78 | PIK3CA (0.65) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA | |
| SCHEMBL3149976 | 0.78 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG | 2010-03-25 | — | — | US | disclosed |
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG | 2010-03-25 | — | — | US | disclosed |
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | NOVARTIS AG | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075965-A1 | PI3 KINASE INHIBITORS AND METHODS OF THEIR USE | PIK3CA, PIK3CD, PIK3CB | PIK3CA 1/4885PIK3CD 2/4885PIK3CB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.