Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 20/20 | 0.78 |
| ▸ | ABL1 | P00519 | 7/20 | 0.78 |
| ▸ | ABL2 | P42684 | 5/20 | 0.78 |
| ▸ | BCR | P11274 | 3/20 | 0.74 |
| ▸ | FYN | P06241 | 2/20 | 0.74 |
| ▸ | STK25 | O00506 | 1/20 | 0.74 |
| ▸ | CIT | O14578 | 1/20 | 0.74 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.74 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.74 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.74 |
| ▸ | CASK | O14936 | 1/20 | 0.74 |
| ▸ | GAK | O14976 | 1/20 | 0.74 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.74 |
| ▸ | MAP3K13 | O43283 | 1/20 | 0.74 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.74 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.74 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.74 |
| ▸ | JAK2 | O60674 | 1/20 | 0.74 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.74 |
| ▸ | ULK1 | O75385 | 1/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL677192 | 0.91 | SRC (0.93) | SRCABL1ABL2BCRFYN | |
| SCHEMBL30452986 | 0.91 | SRC (0.93) | SRCABL1ABL2BCRFYN | |
| SCHEMBL30453438 | 0.91 | SRC (0.92) | SRCABL1ABL2BCRFYN | |
| SCHEMBL676580 | 0.91 | SRC (0.92) | SRCABL1ABL2BCRFYN | |
| SCHEMBL30453343 | 0.89 | SRC (0.92) | SRCABL1ABL2BCRFYN | |
| SCHEMBL676669 | 0.89 | SRC (0.92) | SRCABL1ABL2BCRFYN | |
| SCHEMBL30454025 | 0.89 | SRC (0.94) | SRCABL1ABL2BCRFYN | |
| SCHEMBL677210 | 0.89 | SRC (0.94) | SRCABL1ABL2BCRFYN | |
| SCHEMBL30453202 | 0.89 | SRC (0.85) | SRCABL1ABL2BCRFYN | |
| SCHEMBL676654 | 0.89 | SRC (0.85) | SRCABL1ABL2BCRFYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002009-A2 | TREATMENT OF IMATINIB RESISTANT LEUKEMIA USING 4-AMINOQUINOLINE-3-CARBONITRILES | Wyeth LLC (US) | 2016-04-06 | — | — | EP | claimed |
| EP-2777704-A2 | Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles | Wyeth LLC (US) | 2014-09-17 | — | — | EP | claimed |
| EP-2478905-A2 | Treatment of imatinib resistant leukemia using 4-aminoquinoline-3-carbonitriles | Wyeth LLC (US) | 2012-07-25 | — | — | EP | claimed |
| EP-2152267-A2 | TREATMENT OF IMATINIB RESISTANT LEUKEMIA USING 4-AMINOQUINOLINE-3-CARBONITRILES | Wyeth LLC (US) | 2010-02-17 | — | — | EP | claimed |
| WO-2008150957-A2 | TREATMENT OF IMATINIB RESISTANT LEUKEMIA USING 4-AMINOQUINOLINE-3-CARBONITRILES | WYETH (US) | 2008-12-11 | — | — | WO | claimed |