Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Cefuroxime. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 8/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 1.00 |
| ▸ | PGR | P06401 | 1/20 | 1.00 |
| ▸ | TSHR | P16473 | 1/20 | 1.00 |
| ▸ | MAPT | P10636 | 7/20 | 0.86 |
| ▸ | POLB | P06746 | 2/20 | 0.86 |
| ▸ | PKM | P14618 | 2/20 | 0.86 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.86 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.86 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.78 |
| ▸ | PDE4A | P27815 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
| ▸ | SLC22A6 | Q4U2R8 | 2/20 | 0.59 |
| ▸ | SLC22A8 | Q8TCC7 | 2/20 | 0.59 |
| ▸ | SLC22A11 | Q9NSA0 | 2/20 | 0.59 |
| ▸ | ALB | P02768 | 1/20 | 0.59 |
| ▸ | PPARG | P37231 | 1/20 | 0.59 |
| ▸ | HTR2C | P28335 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cefuroxime SCHEMBL40415 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL2221559 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL11243712 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL40413 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL3861498 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL1821942 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL10907122 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL11549178 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL20535121 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR | |
| Cefuroxime SCHEMBL40414 | 1.00 | TDP1 (1.00) | TDP1HSD17B10NR1I2ALDH1A1PGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119733055-A | Composition of beta-lactam inhibitor and cephalosporin medicine, and preparation method and application thereof | 福建泽瑞药业有限公司 | 2025-04-01 | — | — | CN | disclosed |