Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.42 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.42 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | ESRRG | P62508 | 1/20 | 0.40 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.39 |
| ▸ | WNT1 | P04628 | 2/20 | 0.39 |
| ▸ | GSK3B | P49841 | 2/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.38 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1742792 | 0.93 | TLR9 (0.46) | KDM4EMAPTALDH1A1TLR9TLR8 | |
| SCHEMBL1744088 | 0.82 | PIK3C3 (0.46) | TLR9TLR8TLR7PTPN11 | |
| SCHEMBL1744440 | 0.80 | TLR9 (0.48) | TLR9TLR8TLR7WNT1GSK3B | |
| SCHEMBL1742863 | 0.78 | KDM4E (0.46) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1743029 | 0.77 | KDM4E (0.54) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1741619 | 0.76 | JAK2 (0.42) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1742775 | 0.75 | KDM4E (0.46) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1742297 | 0.75 | HRH3 (0.50) | KDM4EALDH1A1TLR9TLR8TLR7 | |
| SCHEMBL1744142 | 0.74 | HTT (0.42) | PTPN11ESRRGDYRK1A | |
| SCHEMBL1742838 | 0.73 | AKR1C3 (0.46) | TLR9TLR8TLR7PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2233470-A1 | Histamine H3 receptor antagonists | High Point Pharmaceuticals, LLC (US) | 2010-09-29 | — | — | EP | disclosed |