Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.76 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | GFER | P55789 | 1/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.67 |
| ▸ | MTOR | P42345 | 1/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.67 |
| ▸ | PRKDC | P78527 | 1/20 | 0.67 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.67 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 9/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 4/20 | 0.59 |
| ▸ | TTR | P02766 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14050726 | 0.93 | MAPT (0.75) | MAPTPOLBGFERPIK3CDPIK3CA | |
| SCHEMBL1789458 | 0.93 | MAPT (0.89) | MAPTPOLBGFERPIK3CDPIK3CA | |
| SCHEMBL15457561 | 0.93 | MAPT (0.75) | MAPTPOLBGFERPIK3CDPIK3CA | |
| SCHEMBL3132521 | 0.92 | MAPT (0.74) | MAPTPOLBGFERPIK3CDPIK3CA | |
| SCHEMBL12652805 | 0.90 | MAPT (0.70) | MAPTPOLBGFERPIK3CDPIK3CA | |
| SCHEMBL1791417 | 0.90 | MAPT (0.70) | MAPTPOLBGFERPIK3CDPIK3CA | |
| SCHEMBL3137612 | 0.89 | MAPT (0.79) | MAPTPOLBGFERPIK3CDPIK3CA | |
| SCHEMBL1792165 | 0.87 | MAPT (0.65) | MAPTPOLBGFERPIK3CDPIK3CA | |
| SCHEMBL1793447 | 0.86 | MAPT (1.00) | MAPTPOLBGFERMEN1KMT2A | |
| SCHEMBL189385 | 0.85 | PIK3CG (0.67) | MAPTPIK3CDPIK3CAPIK3CBMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140100215-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2014-04-10 | — | — | US | disclosed |
| US-8642584-B2 | Method of using PI3K and MEK modulators | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-8642584-B2 | Method of using PI3K and MEK modulators | EXELIXIS, INC. (US) | 2014-02-04 | — | — | US | disclosed |
| US-20120302545-A1 | Method of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2012-11-29 | — | — | US | disclosed |
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | EXELIXIS, INC. (US) | 2010-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075947-A1 | Methods of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | MAPT 4580/4885POLB 1302/4885GFER 4703/4885 |
| US-20140100215-A1 | Methods of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | MAPT 4580/4885POLB 1302/4885GFER 4703/4885 |
| US-20120302545-A1 | Method of Using PI3K and MEK Modulators | PIK3CA, PIK3CD, PIK3R1 | MAPT 4606/4885POLB 1498/4885GFER 4682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.