Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 6/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31479974 | 0.78 | MEN1 (0.50) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL19629886 | 0.77 | KCNN4 (0.46) | SMN1; SMN2LMNAALDH1A1MAPK1KCNN4 | |
| SCHEMBL5461543 | 0.77 | MEN1 (0.56) | MEN1KMT2ATDP1MAOAMAPT | |
| SCHEMBL27661323 | 0.75 | TAAR1 (0.50) | MEN1KMT2ALMNAALDH1A1MAPK1 | |
| SCHEMBL11162021 | 0.75 | MEN1 (0.54) | MEN1KMT2ATDP1ALDH1A1MAOA | |
| Trimethylammonium SCHEMBL27861478 | 0.74 | MEN1 (0.64) | MEN1KMT2ATDP1ALDH1A1MAOA | |
| SCHEMBL15114181 | 0.73 | MEN1 (0.58) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL2013167 | 0.73 | MEN1 (0.57) | MEN1KMT2ATDP1SMN1; SMN2LMNA | |
| SCHEMBL4588005 | 0.73 | MEN1 (0.52) | MEN1KMT2ATDP1MAOAMAPT | |
| SCHEMBL3926325 | 0.73 | SLC6A2 (0.54) | MEN1KMT2ATDP1MAOAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250051434-A1 | MONOVALENT INTERLEUKIN 12 (IL-12) HETERODIMERIC FC PROTEINS | MERCK SHARP & DOHME LLC (US) | 2025-02-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250051434-A1 | MONOVALENT INTERLEUKIN 12 (IL-12) HETERODIMERIC FC PROTEINS | IL2RA, IL2, FCGR2A | MEN1 1701/4885KMT2A 2295/4885TDP1 4828/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.