SCHEMBL31483007

SCHEMBL31483007

COc1cc(-c2ccc3nc(NC(=O)NCCOc4ccccc4)cn3n2)cnc1OC

nearest known ligand 0.88

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 12/20 0.88
PIK3CG P48736 11/20 0.88
PIK3CD O00329 5/20 0.88
RIPK1 Q13546 6/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31483034 0.94 PIK3CG (1.00) PIK3CAPIK3CGPIK3CD
SCHEMBL31483038 0.86 PIK3CG (0.86) PIK3CAPIK3CGPIK3CDRIPK1
SCHEMBL12664700 0.83 PIK3CA (0.62) PIK3CAPIK3CGPIK3CDRIPK1
SCHEMBL2920182 0.82 PIK3CA (0.80) PIK3CAPIK3CGPIK3CDRIPK1
SCHEMBL31483012 0.78 PIK3CG (1.00) PIK3CAPIK3CGPIK3CD
SCHEMBL12664676 0.78 PIK3CA (0.60) PIK3CAPIK3CGPIK3CDRIPK1
SCHEMBL12664673 0.77 PIK3CA (0.59) PIK3CAPIK3CGPIK3CDRIPK1
SCHEMBL12664715 0.76 PIK3CA (0.58) PIK3CAPIK3CGPIK3CDRIPK1
SCHEMBL12664726 0.75 PIK3CA (0.57) PIK3CAPIK3CGPIK3CDRIPK1
SCHEMBL12664368 0.75 PIK3CA (0.57) PIK3CAPIK3CGPIK3CDRIPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119841829-A Compounds for the treatment of PI3K gamma mediated diseases and uses thereof 中国科学院合肥物质科学研究院 2025-04-18 CN disclosed