Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | MC4R | P32245 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | MC3R | P41968 | 1/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29598957 | 0.86 | NISCH (0.50) | HCAR2KDM4ENAPRTADORA3TSHR | |
| SCHEMBL78566 | 0.86 | NISCH (0.50) | HCAR2KDM4ENAPRTADORA3TSHR | |
| SCHEMBL29454745 | 0.86 | NISCH (0.50) | HCAR2KDM4ENAPRTADORA3TSHR | |
| SCHEMBL31372462 | 0.83 | NISCH (0.48) | HCAR2KDM4ENAPRTADORA3TSHR | |
| SCHEMBL14053846 | 0.83 | NISCH (0.48) | HCAR2KDM4ENAPRTADORA3TSHR | |
| Hydrochloric Acid SCHEMBL3640139 | 0.83 | NISCH (0.48) | HCAR2KDM4ENAPRTADORA3TSHR | |
| SCHEMBL9794662 | 0.83 | NISCH (0.48) | HCAR2KDM4ENAPRTADORA3TSHR | |
| SCHEMBL1830422 | 0.81 | KDM4E (0.64) | HCAR2KDM4ENAPRTADORA3TSHR | |
| Hydrochloric Acid SCHEMBL30272980 | 0.80 | NISCH (0.46) | HCAR2KDM4ENAPRTADORA3TSHR | |
| SCHEMBL30253050 | 0.80 | KDM4E (0.47) | HCAR2KDM4ENAPRTADORA3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119775215-A | Spin-control-induced CO2 reduction catalytic material and preparation and application methods thereof | 常州大学 | 2025-04-08 | — | — | CN | disclosed |