Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 6/20 | 0.41 |
| ▸ | IGF1R | P08069 | 6/20 | 0.41 |
| ▸ | FLT4 | P35916 | 6/20 | 0.41 |
| ▸ | KDR | P35968 | 6/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | FABP3 | P05413 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3145213 | 0.89 | SRC (0.41) | EGFRIGF1RFLT4KDRPOLB | |
| SCHEMBL3139629 | 0.88 | EGFR (0.41) | EGFRIGF1RFLT4KDRPOLB | |
| SCHEMBL1876524 | 0.84 | PTGDR2 (0.45) | POLBFABP3FABP4PTGDR2HDAC3 | |
| SCHEMBL12637204 | 0.84 | PTGDR2 (0.45) | POLBFABP3FABP4PTGDR2HDAC3 | |
| SCHEMBL14624167 | 0.83 | EGFR (0.43) | EGFRIGF1RFLT4KDRPOLB | |
| SCHEMBL1879091 | 0.82 | EGFR (0.42) | EGFRIGF1RFLT4KDRPOLB | |
| Hydrochloric Acid SCHEMBL1879366 | 0.82 | EGFR (0.44) | EGFRIGF1RFLT4KDRPOLB | |
| SCHEMBL3148454 | 0.81 | FABP3 (0.41) | POLBFABP3KDM4EPKMHTT | |
| SCHEMBL1875425 | 0.80 | EGFR (0.41) | EGFRIGF1RFLT4KDRPOLB | |
| Hydrochloric Acid SCHEMBL1881378 | 0.79 | EGFR (0.42) | EGFRIGF1RFLT4KDRPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1902026-B1 | TETRAHYDROCARBAZOLE DERIVATIVES USEFUL AS ANDROGEN RECEPTOR MODULATORS (SARM) | LILLY CO ELI (US) | 2010-02-17 | — | — | EP | disclosed |