SCHEMBL31487461

SCHEMBL31487461

CC(C)(C)OC(=O)N1CCN(c2cc(Cl)c(NC3CCC(=O)NC3=O)cc2F)CC1

nearest known ligand 0.56

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 15/20 0.56
DDB1 Q16531 14/20 0.56
MAPT P10636 3/20 0.42
STS P08842 1/20 0.40
KDM4E B2RXH2 1/20 0.39
THRB P10828 1/20 0.39
USP30 Q70CQ3 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30965667 1.00 CRBN (0.56) CRBNDDB1MAPTSTSKDM4E
SCHEMBL30965722 0.93 CRBN (0.60) CRBNDDB1MAPTKDM4ETHRB
SCHEMBL30965726 0.90 CRBN (0.57) CRBNDDB1MAPTTHRB
SCHEMBL25219715 0.89 CRBN (0.56) CRBNDDB1STS
SCHEMBL30965610 0.84 DDB1 (0.53) CRBNDDB1
SCHEMBL30965774 0.84 CRBN (0.56) CRBNDDB1MAPTKDM4ETHRB
SCHEMBL31451251 0.83 DDB1 (0.68) CRBNDDB1
SCHEMBL29535454 0.83 DDB1 (0.68) CRBNDDB1
SCHEMBL25027239 0.83 DDB1 (0.68) CRBNDDB1
SCHEMBL25634557 0.83 DDB1 (0.68) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119790057-A Novel PLK1 degradation inducing compounds 厄普特拉株式会社 2025-04-08 CN disclosed