SCHEMBL31489681

SCHEMBL31489681

Cc1cn2nc(N)nc2cc1-c1nc(-c2cnn([C@H](c3ccc(F)cc3)C(C)(F)F)c2)ccc1F

nearest known ligand 0.33

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PIK3CG P48736 2/20 0.33
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
FGFR1 P11362 1/20 0.30
FGFR2 P21802 1/20 0.30
FGFR3 P22607 1/20 0.30
PIK3CD O00329 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489471 0.87 PIK3CG (0.38) PIK3CGFGFR1FGFR2FGFR3PIK3CD
SCHEMBL31489415 0.85 PIK3CG (0.38) PIK3CGPIK3CD
SCHEMBL31489782 0.84 PIK3CG (0.32) PIK3CGPIK3CD
SCHEMBL31489692 0.83 PIK3CG (0.38) PIK3CGPIK3CD
SCHEMBL31489198 0.83 PIK3CG (0.33) PIK3CGPIK3CD
SCHEMBL31489864 0.82 PIK3CG (0.37) PIK3CGPIK3CD
SCHEMBL31489610 0.81 PIK3CG (0.43) PIK3CGPIK3CD
SCHEMBL31489839 0.81 PIK3CG (0.43) PIK3CGPIK3CD
SCHEMBL31489733 0.80 PIK3CG (0.34) PIK3CGPIK3CD
SCHEMBL31489411 0.79 PIK3CG (0.40) PIK3CGPIK3CD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed