SCHEMBL31489773

SCHEMBL31489773

Cc1c(-c2nccc(-c3cnn([C@H](c4ccc(F)cc4)C(C)(F)F)c3)n2)ccn2nc(-n3c(C)ccc3C)nc12

nearest known ligand 0.33

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 1/20 0.33
PIK3CA P42336 1/20 0.33
PIK3CG P48736 1/20 0.33
NTRK1 P04629 1/20 0.30
MKNK1 Q9BUB5 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31489181 0.94 PIK3CD (0.33) PIK3CDPIK3CAPIK3CGNTRK1MKNK1
SCHEMBL31489554 0.88 NTRK1 (0.32) PIK3CDPIK3CAPIK3CGNTRK1
SCHEMBL31489279 0.88
SCHEMBL31489460 0.88 PIK3CD (0.36) PIK3CDPIK3CAPIK3CGMKNK1
SCHEMBL31489890 0.86 PIK3CD (0.30) PIK3CDPIK3CAPIK3CGMKNK1
SCHEMBL31489334 0.85 NTRK1 (0.30) NTRK1
SCHEMBL31489194 0.85
SCHEMBL31489280 0.85 NTRK1 (0.33) PIK3CDPIK3CAPIK3CGNTRK1
SCHEMBL31489732 0.82 PIK3CD (0.36) PIK3CDPIK3CAPIK3CGNTRK1MKNK1
SCHEMBL31489596 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025072395-A1 TRIAZOLOPYRIDINYL COMPOUNDS AS KINASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2025-04-03 WO disclosed