SCHEMBL31491103

SCHEMBL31491103

CC(C)(C)OC(=O)N1CCN(CCCN2CCN(c3ccc4c(c3)C(=O)N(C3CCC(=O)NC3=O)C4=O)CC2)CC1

nearest known ligand 0.59

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 15/20 0.59
DDB1 Q16531 8/20 0.53
HPGDS O60760 2/20 0.49
AR P10275 1/20 0.47
BRD9 Q9H8M2 1/20 0.47
CCNC P24863 1/20 0.47
CDK8 P49336 1/20 0.47
IRAK1 P51617 1/20 0.47
NTRK3 Q16288 1/20 0.47
HASPIN Q8TF76 1/20 0.47
CDK19 Q9BWU1 1/20 0.47
IRAK4 Q9NWZ3 1/20 0.47
IRAK3 Q9Y616 1/20 0.47
RAF1 P04049 2/20 0.46
EGFR P00533 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31491096 1.00 CRBN (0.59) CRBNDDB1HPGDSARBRD9
SCHEMBL31491134 0.98 CRBN (0.59) CRBNDDB1HPGDSARBRD9
SCHEMBL31491115 0.98 CRBN (0.59) CRBNDDB1HPGDSARBRD9
SCHEMBL31491098 0.95 CRBN (0.54) CRBNDDB1HPGDSARBRD9
SCHEMBL27035944 0.94 CRBN (0.56) CRBNDDB1HPGDSARBRD9
SCHEMBL31411061 0.94 CRBN (0.56) CRBNDDB1HPGDSARBRD9
SCHEMBL20305725 0.94 CRBN (0.54) CRBNDDB1HPGDSARBRD9
SCHEMBL20046281 0.93 CRBN (0.67) CRBNDDB1HPGDS
SCHEMBL29629059 0.93 CRBN (0.67) CRBNDDB1HPGDS
SCHEMBL22297514 0.93 CRBN (0.67) CRBNDDB1HPGDS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025073251-A1 COMPOUND CAPABLE OF DEGRADING EPIDERMAL GROWTH FACTOR RECEPTOR, AND USE THEREOF 普美瑞(苏州)生物科技有限公司 2025-04-10 WO disclosed