Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 17/20 | 0.76 |
| ▸ | MC3R | P41968 | 4/20 | 0.76 |
| ▸ | MC1R | Q01726 | 4/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MC5R | P33032 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3143486 | 0.98 | MC4R (0.78) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL3159794 | 0.94 | MC4R (0.71) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL3156514 | 0.94 | MC4R (0.71) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL3148314 | 0.94 | MC4R (0.73) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL3148321 | 0.94 | MC4R (0.73) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL3152961 | 0.94 | MC4R (0.73) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL3149435 | 0.94 | MC4R (0.73) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL3152966 | 0.94 | MC4R (0.73) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL5476125 | 0.94 | MC4R (0.73) | MC4RMC3RMC1RALDH1A1KDM4E | |
| SCHEMBL3156471 | 0.94 | MC4R (0.78) | MC4RMC3RMC1RALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773796-B1 | OXOPIPERIDINE DERIVATIVES, PREPARATION AND THERAPEUTIC USE THEREOF | SANOFI AVENTIS (FR) | 2010-03-03 | — | — | EP | claimed |