Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4247874 | 0.99 | KMT2A (0.42) | KMT2ADPP4DPP8BCHEMAOA | |
| SCHEMBL3152625 | 0.92 | DPP4 (0.43) | KMT2ADPP4DPP8BCHEMAOA | |
| Hydrochloric Acid SCHEMBL4247185 | 0.91 | DPP4 (0.42) | KMT2ADPP4DPP8BCHEMAOA | |
| SCHEMBL3149457 | 0.87 | KMT2A (0.45) | KMT2ADPP4DPP8ABCB1ABCC1 | |
| SCHEMBL3145228 | 0.87 | KMT2A (0.55) | KMT2ADPP4DPP8ABCB1ABCC1 | |
| SCHEMBL3162393 | 0.87 | ABCB1 (0.46) | KMT2ADPP4DPP8ABCB1ABCC1 | |
| Hydrochloric Acid SCHEMBL4253485 | 0.87 | KMT2A (0.44) | KMT2ADPP4DPP8ABCB1ABCC1 | |
| SCHEMBL3163086 | 0.86 | DPP4 (0.45) | KMT2ADPP4DPP8ABCB1ABCC1 | |
| Hydrochloric Acid SCHEMBL4250142 | 0.86 | KMT2A (0.54) | KMT2ADPP4DPP8ABCB1ABCC1 | |
| SCHEMBL3143069 | 0.86 | CHRM2 (0.46) | KMT2ABCHEMAOAACHEMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |