Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4244389 | 0.99 | KMT2A (0.47) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3157351 | 0.93 | KMT2A (0.47) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| Hydrochloric Acid SCHEMBL4254392 | 0.92 | KMT2A (0.47) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3153786 | 0.89 | CHRM2 (0.48) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL4250522 | 0.88 | KMT2A (0.41) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3143069 | 0.88 | CHRM2 (0.46) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| Hydrochloric Acid SCHEMBL4242663 | 0.88 | CHRM2 (0.47) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| Hydrochloric Acid SCHEMBL4247826 | 0.87 | CHRM2 (0.45) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3155094 | 0.87 | CHRM2 (0.47) | KMT2ACHRM2HTR1ASLC6A4DRD3 | |
| SCHEMBL3155003 | 0.87 | CHRM2 (0.47) | KMT2ACHRM2HTR1ASLC6A4DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |