Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4250876 | 0.99 | DPP4 (0.45) | DPP4DPP8KMT2ACYP3A4CYP2D6 | |
| SCHEMBL3155041 | 0.92 | DPP4 (0.49) | DPP4DPP8KMT2AHTTL3MBTL1 | |
| SCHEMBL3144330 | 0.92 | DPP4 (0.49) | DPP4DPP8KMT2AHTTL3MBTL1 | |
| Hydrochloric Acid SCHEMBL4248376 | 0.91 | DPP4 (0.48) | DPP4DPP8KMT2AHTTL3MBTL1 | |
| SCHEMBL3149531 | 0.87 | DPP4 (0.46) | DPP4DPP8KMT2AHTTTP53 | |
| SCHEMBL3157230 | 0.87 | DPP4 (0.45) | DPP4DPP8KMT2AMTNR1BMTNR1A | |
| SCHEMBL3145228 | 0.87 | KMT2A (0.55) | DPP4DPP8KMT2AGAAHTT | |
| SCHEMBL3162393 | 0.87 | ABCB1 (0.46) | DPP4DPP8KMT2AABCB1ABCC1 | |
| Hydrochloric Acid SCHEMBL4251956 | 0.87 | DPP4 (0.45) | DPP4DPP8KMT2AHTTL3MBTL1 | |
| SCHEMBL3163056 | 0.87 | DPP4 (0.45) | DPP4DPP8KMT2AHTTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |