Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Belotecan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 known ✓ | P11387 | 18/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | GLA | P06280 | 3/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | TP53 | P04637 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 2/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.61 |
| ▸ | STAT6 | P42226 | 1/20 | 0.61 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.61 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.61 |
| ▸ | GMNN | O75496 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | HNRNPA1 | P09651 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Belotecan SCHEMBL7869454 | 1.00 | TOP1 (0.78) | TOP1MEN1KMT2AALDH1A1GLA | |
| Belotecan SCHEMBL29378860 | 0.99 | TOP1 (0.79) | TOP1MEN1KMT2AALDH1A1GLA | |
| Belotecan SCHEMBL21410040 | 0.99 | TOP1 (0.79) | TOP1MEN1KMT2AALDH1A1GLA | |
| Belotecan SCHEMBL18983 | 0.99 | TOP1 (0.79) | TOP1MEN1KMT2AALDH1A1GLA | |
| Belotecan SCHEMBL1651143 | 0.98 | TOP1 (0.76) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL2462051 | 0.92 | TOP1 (0.76) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL22843978 | 0.91 | TOP1 (0.82) | TOP1MEN1KMT2AALDH1A1GLA | |
| Hydrochloric Acid SCHEMBL4234927 | 0.90 | TOP1 (0.81) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL25845670 | 0.90 | TOP1 (0.64) | TOP1MEN1KMT2AALDH1A1GLA | |
| SCHEMBL31726483 | 0.90 | TOP1 (0.72) | TOP1MEN1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025088175-A1 | ALC1 INHIBITORS FOR USE IN TREATING CANCER BY POTENTIATING THE EFFECTS OF SEVERAL CLASSES OF APPROVED CANCER DRUGS | EISBACH BIO GMBH (DE) | 2025-05-01 | — | — | WO | disclosed |