Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 4/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.48 |
| ▸ | WNT1 | P04628 | 2/20 | 0.48 |
| ▸ | UCHL1 | P09936 | 3/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | FPR3 | P25089 | 1/20 | 0.39 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | FFAR2 | O15552 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31272043 | 0.84 | MKNK1 (0.66) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25612252 | 0.82 | MKNK1 (0.64) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605170 | 0.80 | MKNK1 (0.74) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25612325 | 0.80 | MKNK1 (0.60) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25612253 | 0.78 | MKNK1 (0.61) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605337 | 0.76 | MKNK1 (0.64) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605166 | 0.76 | MKNK1 (0.58) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605336 | 0.75 | MKNK1 (0.59) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25605169 | 0.74 | MKNK1 (0.56) | MKNK1GSK3BDYRK1AWNT1UCHL1 | |
| SCHEMBL25859144 | 0.74 | MKNK1 (0.64) | MKNK1GSK3BDYRK1AWNT1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066318-A1 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | PROTHENA BIOSCIENCES INC | 2025-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066318-A1 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | DYRK1A, DYRK2, DYRK1B | MKNK1 105/4885GSK3B 121/4885DYRK1A 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.