SCHEMBL31526348

SCHEMBL31526348

COc1ncnc(-c2ccccc2)c1CSC[C@H]1O[C@@H](n2ccc3c(N)ncnc32)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.40

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ DNMT1 P26358 1/20 0.40
▸ DNMT3B Q9UBC3 1/20 0.40
▸ ADK P55263 2/20 0.38
▸ PRMT5 O14744 13/20 0.38
▸ WDR77 Q9BQA1 10/20 0.38
▸ METTL3 Q86U44 3/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31526259 0.91 DNMT1 (0.41) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526138 0.88 DNMT1 (0.40) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526155 0.87 DNMT1 (0.40) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526246 0.87 DNMT1 (0.40) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526242 0.87 DNMT1 (0.40) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526132 0.86 DNMT1 (0.39) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526116 0.85 DNMT1 (0.41) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526281 0.85 DNMT1 (0.41) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526257 0.85 DNMT1 (0.41) DNMT1DNMT3BADKPRMT5WDR77
SCHEMBL31526099 0.85 DNMT1 (0.56) DNMT1DNMT3BADKPRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025098545-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES USTAV ORGANICKE CHEMIE A BIOCHEMIE AV CR, V. V. I. (CZ) 2025-05-15 — — WO disclosed
EP-4553080-A1 NUCLEOSIDE DERIVATIVES AS ANTIVIRAL AGENTS AGAINST CORONAVIRUSES Ustav Organicke Chemie a Biochemie AV CR, v.v.i. (CZ) 2025-05-14 — — EP disclosed
Send feedback