Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27018597 | 0.81 | SPHK1 (0.46) | SPHK1BRD4NR1H2HSD11B2HCRTR2 | |
| SCHEMBL31526584 | 0.80 | SPHK1 (0.38) | SPHK1BRD4HSD11B2 | |
| SCHEMBL31526458 | 0.80 | SPHK1 (0.42) | SPHK1BRD4HSD11B2HCRTR2CHRM2 | |
| SCHEMBL1526136 | 0.78 | SPHK1 (0.50) | SPHK1BRD4NR1H2HSD11B2HCRTR2 | |
| SCHEMBL1067807 | 0.78 | SPHK1 (0.50) | SPHK1BRD4NR1H2HSD11B2HCRTR2 | |
| SCHEMBL1067809 | 0.78 | SPHK1 (0.50) | SPHK1BRD4NR1H2HSD11B2HCRTR2 | |
| SCHEMBL28821227 | 0.74 | SPHK1 (0.44) | SPHK1BRD4NR1H2HSD11B2HCRTR2 | |
| SCHEMBL30453637 | 0.74 | SPHK1 (0.44) | SPHK1BRD4NR1H2HSD11B2HCRTR2 | |
| SCHEMBL28821226 | 0.74 | SPHK1 (0.44) | SPHK1BRD4NR1H2HSD11B2HCRTR2 | |
| SCHEMBL17520115 | 0.73 | SPHK1 (0.50) | SPHK1BRD4NR1H2HSD11B2HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025076235-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2025-04-10 | — | — | WO | disclosed |