Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4243289 | 0.99 | CHRM2 (0.48) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| SCHEMBL3154135 | 0.98 | CHRM2 (0.48) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL4244565 | 0.95 | CHRM2 (0.49) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| Fumaric Acid SCHEMBL4250550 | 0.93 | CHRM2 (0.45) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| Fumaric Acid SCHEMBL4250537 | 0.93 | CHRM2 (0.45) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| SCHEMBL3145945 | 0.88 | CHRM2 (0.52) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL4251399 | 0.86 | CHRM2 (0.50) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| SCHEMBL301711 | 0.85 | CHRM2 (0.62) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| SCHEMBL3154423 | 0.85 | CHRM2 (0.62) | CHRM2HTR1ASLC6A4DRD3KCNH2 | |
| Hydrochloric Acid SCHEMBL4244379 | 0.84 | CHRM2 (0.61) | CHRM2HTR1ASLC6A4DRD3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2036892-B1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2010-03-10 | — | — | EP | disclosed |
| EP-2036892-A1 | 1,2,4,5-tetrahydro-3H-benzazepine derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2009-03-18 | — | — | EP | disclosed |