SCHEMBL31536446

C[C@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccccc1)[C@@H](C)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(N)=O

nearest known ligand 0.78

Predicted protein targets (top 4)

	gene	UniProt	supporting neighbours	confidence
▸	OPRL1	P41146	12/20	0.78

▸	FURIN	P09958	1/20	0.56

▸	QRFPR	Q96P65	1/20	0.56

▸	NPBWR1	P48145	1/20	0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL31536447	1.00	OPRL1 (0.78)	OPRL1FURINQRFPRNPBWR1
SCHEMBL29355633	1.00	OPRL1 (0.78)	OPRL1FURINQRFPRNPBWR1
SCHEMBL31536444	0.93	OPRL1 (0.78)	OPRL1FURINQRFPR
SCHEMBL31536443	0.93	OPRL1 (0.78)	OPRL1FURINQRFPR
SCHEMBL29623262	0.93	OPRL1 (0.78)	OPRL1FURINQRFPR
Nociceptin-Nh2 SCHEMBL30033176	0.92	OPRL1 (0.79)	OPRL1
Nociceptin SCHEMBL29358223	0.88	OPRL1 (0.79)	OPRL1
SCHEMBL27915864	0.84	OPRL1 (0.54)	OPRL1
SCHEMBL30974017	0.82	OPRL1 (0.62)	OPRL1
SCHEMBL30980377	0.81	OPRL1 (0.58)	OPRL1NPBWR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
WO-2025085826-A1	ACTIVATION OF ORL1: A NOVEL THERAPY TO PREVENT HEART FAILURE PROGRESSION	BAYLOR COLLEGE OF MEDICINE (US)	2025-04-24	—	—	WO	claimed
WO-2025085826-A1	ACTIVATION OF ORL1: A NOVEL THERAPY TO PREVENT HEART FAILURE PROGRESSION	BAYLOR COLLEGE OF MEDICINE (US)	2025-04-24	—	—	WO	disclosed