⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303479 | 0.82 | NOTUM (0.43) | — | |
| SCHEMBL18914801 | 0.81 | TNKS2 (0.38) | — | |
| SCHEMBL10283737 | 0.81 | — | — | |
| SCHEMBL26928299 | 0.80 | NOTUM (0.44) | — | |
| SCHEMBL10157733 | 0.79 | — | — | |
| SCHEMBL441859 | 0.79 | — | — | |
| SCHEMBL15290013 | 0.79 | — | — | |
| SCHEMBL3765497 | 0.79 | — | — | |
| SCHEMBL3154091 | 0.79 | — | — | |
| Hydrochloric Acid SCHEMBL440017 | 0.78 | NOTUM (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3684773-B1 | THAILANSTATIN ANALOGS | PH PHARMA CO LTD (KR) | 2026-04-29 | — | — | EP | disclosed |
| US-20240208992-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2024-06-27 | — | — | US | disclosed |
| EP-4308575-A1 | MACROCYCLES AS CFTR MODULATORS | Idorsia Pharmaceuticals Ltd (CH) | 2024-01-24 | — | — | EP | disclosed |
| CN-111788208-B | Talarstatin analogues | PH制药有限公司 | 2023-11-24 | — | — | CN | disclosed |
| CN-116981672-A | Macrocyclic compounds as CFTR modulators | 爱杜西亚药品有限公司 | 2023-10-31 | — | — | CN | disclosed |
| US-11691982-B2 | Thailanstatin analogs | PH PHARMA CO., LTD. (KR) | 2023-07-04 | — | — | US | disclosed |
| US-11691982-B2 | Thailanstatin analogs | PH PHARMA CO., LTD. (KR) | 2023-07-04 | — | — | US | disclosed |
| US-11691982-B2 | Thailanstatin analogs | PH PHARMA CO., LTD. (KR) | 2023-07-04 | — | — | US | disclosed |
| WO-2022194399-A1 | MACROCYCLES AS CFTR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2022-09-22 | — | — | WO | disclosed |
| US-20200407369-A1 | THAILANSTATIN ANALOGS | PH PHARMA CO., LTD. (KR) | 2020-12-31 | — | — | US | disclosed |
| EP-0691962-A1 | 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE | BASF AKTIENGESELLSCHAFT (DE) | 1996-01-17 | — | — | EP | disclosed |
| US-5399696-A | Excitatory amino acid receptor antagonists; nervous system disorders | ELI LILLY AND COMPANY (US) | 1995-03-21 | — | — | US | disclosed |
| WO-1994022842-A1 | 1-AMINO-3-PHENOXY PROPANE DERIVATIVES AS MODULATORS OF MULTI-DRUG RESISTANCE | BASF AKTIENGESELLSCHAFT (DE) | 1994-10-13 | — | — | WO | disclosed |
| EP-0590789-A1 | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1994-04-06 | — | — | EP | disclosed |
| US-5284957-A | Substituted 1H- or 2H-tetrazoles | ELI LILLY AND COMPANY (US) | 1994-02-08 | — | — | US | disclosed |
| EP-0207955-B1 | PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED ISOXAZOLES | ZAMBON S.p.A. (IT) | 1990-02-07 | — | — | EP | disclosed |
| US-4873243-A | ANTIDEPRESSANTS OR PYCHOTONICS | SANOFI (FR) | 1989-10-10 | — | — | US | disclosed |
| US-4772719-A | FROM DIHALOFORMALDOXIME AND ALKYNE, CYCLIZATION | ZAMBON S.P.A. (IT) | 1988-09-20 | — | — | US | disclosed |
| EP-0207955-A1 | PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED ISOXAZOLES. | ZAMBON SPA (IT) | 1987-01-14 | — | — | EP | disclosed |
| WO-1986003490-A1 | PROCESS FOR THE PREPARATION OF 3,5-DISUBSTITUTED ISOXAZOLES | ZAMBON S.P.A. (IT) | 1986-06-19 | — | — | WO | disclosed |