Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 4/20 | 0.58 |
| ▸ | CDK9 | P50750 | 4/20 | 0.58 |
| ▸ | PIM1 | P11309 | 2/20 | 0.55 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 2/20 | 0.55 |
| ▸ | CCND1 | P24385 | 2/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.55 |
| ▸ | PRKCA | P17252 | 1/20 | 0.53 |
| ▸ | PRKACA | P17612 | 1/20 | 0.53 |
| ▸ | PRKACG | P22612 | 1/20 | 0.53 |
| ▸ | PRKACB | P22694 | 1/20 | 0.53 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8161831 | 0.86 | CCNT1 (0.64) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL8161322 | 0.86 | CCNE2 (0.74) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL8166629 | 0.85 | PIM1 (0.59) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL30834692 | 0.85 | CCNT1 (0.56) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL8162035 | 0.83 | PRKACA (0.59) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL8161873 | 0.83 | CCNT1 (0.52) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL8162860 | 0.81 | CCNT1 (0.53) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL8075637 | 0.79 | CCNT1 (0.50) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL3139598 | 0.79 | GSK3B (0.78) | CCNT1CDK9PIM1CAMK2DCDK2 | |
| SCHEMBL14522482 | 0.78 | GSK3B (0.69) | CCNT1CDK9PIM1CAMK2DCDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1449529-B1 | Protein Kinase C Inhibitors | LILLY CO ELI (US) | 2010-01-27 | — | — | EP | disclosed |
| EP-1449529-A1 | Protein Kinase C Inhibitors | ELI LILLY AND COMPANY (US) | 2004-08-25 | — | — | EP | disclosed |
| US-5668152-A | BIS/INDOLE/-SUBSTITUTED MALEIMIDES, ANTIDIABETIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-09-16 | — | — | US | disclosed |
| US-5661173-A | ADMINISTERING AN ENZYME INHIBITOR TREATING DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5545636-A | TREATING DIABETES MELLITUS | ELI LILLY AND COMPANY (US) | 1996-08-13 | — | — | US | disclosed |