Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 13/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3317493 | 0.80 | EPHX2 (0.58) | EPHX2EPHX1MAPTCYP1A2TDP1 | |
| SCHEMBL2888489 | 0.80 | EPHX2 (0.58) | EPHX2EPHX1MAPTCYP1A2TDP1 | |
| Hydrochloric Acid SCHEMBL11313043 | 0.78 | EPHX2 (0.56) | EPHX2EPHX1MAPTCYP1A2TDP1 | |
| SCHEMBL9893075 | 0.78 | EPHX2 (0.67) | EPHX2EPHX1 | |
| SCHEMBL13852062 | 0.78 | EPHX2 (0.56) | EPHX2EPHX1MAPTCYP1A2TDP1 | |
| SCHEMBL12850168 | 0.78 | EPHX2 (0.56) | EPHX2EPHX1MAPTCYP1A2TDP1 | |
| SCHEMBL14175034 | 0.78 | EPHX2 (0.56) | EPHX2EPHX1MAPTCYP1A2TDP1 | |
| SCHEMBL25078298 | 0.78 | EPHX2 (0.51) | EPHX2EPHX1MAPTCYP1A2TDP1 | |
| SCHEMBL2102575 | 0.78 | EPHX2 (0.51) | EPHX2EPHX1MAPT | |
| Hydrochloric Acid SCHEMBL4163207 | 0.77 | EPHX2 (0.55) | EPHX2EPHX1MAPTCYP1A2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101874031-B | Sirtuin-modulating imidazothiazole compounds | SIRTRIS PHARMACEUTICALS INC | 2013-02-20 | — | — | CN | claimed |
| CN-101316853-B | Benzothiazole and thiazolopyridine as SIRTUIN modulators | SIRTRIS PHARMACEUTICALS INC | 2014-09-24 | — | — | CN | disclosed |
| CN-103833775-A | SIRTUIN MODULATING COMPOUNDS | SIRTRIS PHARMACEUTICALS INC | 2014-06-04 | — | — | CN | disclosed |
| CN-103145738-A | Imidazo [2,1-b] thiayole derivatives as SIRTUIN modulating compounds | SIRTRIS PHARMACEUTICALS INC | 2013-06-12 | — | — | CN | disclosed |
| CN-101874031-B | Sirtuin-modulating imidazothiazole compounds | SIRTRIS PHARMACEUTICALS INC | 2013-02-20 | — | — | CN | disclosed |
| US-8093401-B2 | Silent Information Regulators; aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting , increased mitochondrial activity, inflammation, cancer, and/or flushing; increased lifespan specially in mutant sir2 strains; imidazo[1,2-a]pyridine drivatives | SIRTRIS PHARMACEUTICALS, INC. (US) | 2012-01-10 | — | — | US | disclosed |
| CN-101918371-A | Amide derivatives as sirtuin modulators | SIRTRIS PHARMACEUTICALS INC | 2010-12-15 | — | — | CN | disclosed |
| CN-101910184-A | Solubility thiazole and pyridine | SIRTRIS PHARMACEUTICALS INC | 2010-12-08 | — | — | CN | disclosed |
| CN-101874031-A | Sirtuin-modulating imidazothiazole compounds | SIRTRIS PHARMACEUTICALS INC | 2010-10-27 | — | — | CN | disclosed |
| CN-101801981-A | Sirtuin-modulating thiazolopyridine compounds | SIRTRIS PHARMACEUTICALS INC | 2010-08-11 | — | — | CN | disclosed |
| CN-101316853-A | Benzothiazole and thiazolopyridine as SIRTUIN modulators | SIRTRIS PHARMACEUTICALS INC (US) | 2008-12-03 | — | — | CN | disclosed |
| CN-101282974-A | Benzimidazole derivatives as SIRTUIN modulators | SIRTRIS PHARMACEUTICALS INC (US) | 2008-10-08 | — | — | CN | disclosed |
| CN-101277963-A | Benzimidazole derivatives as SIRTUIN modulators | SIRTIS PHARMACEUTICALS INC (US) | 2008-10-01 | — | — | CN | disclosed |
| CN-101277965-A | Imidazo [2, 1-b ] thiazole derivatives as SIRTUIN modulating compounds | SIRTRIS PHARMACEUTICALS INC (US) | 2008-10-01 | — | — | CN | disclosed |