Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 18/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.43 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2800743 | 0.86 | HRH3 (0.59) | HRH3KCNH2 | |
| SCHEMBL2797048 | 0.85 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL2798202 | 0.75 | HRH3 (0.74) | HRH3KCNH2 | |
| SCHEMBL2798554 | 0.74 | HRH3 (0.70) | HRH3KCNH2 | |
| SCHEMBL2799204 | 0.74 | HRH3 (1.00) | HRH3KCNH2 | |
| SCHEMBL2799409 | 0.73 | HRH3 (0.67) | HRH3KCNH2 | |
| SCHEMBL6793505 | 0.72 | HRH3 (0.47) | HRH3ITGB3ITGA2B | |
| SCHEMBL2797749 | 0.71 | HRH3 (0.69) | HRH3KCNH2 | |
| SCHEMBL2799847 | 0.71 | HRH3 (0.69) | HRH3KCNH2 | |
| SCHEMBL2844348 | 0.71 | HRH3 (0.79) | HRH3ITGB3ITGA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162452-A1 | SPIROCYCLOPROPYL PIPERIDINE DERIVATIVES | AstraZeneca AB (SE) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008147314-A1 | SPIROCYCLOPROPYL PIPERIDINE DERIVATIVES | ASTRAZENECA AB (SE) | 2008-12-04 | — | — | WO | disclosed |