Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of T-Butylacetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.42 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| T-Butylacetic Acid SCHEMBL973429 | 0.97 | — | — | |
| T-Butylacetic Acid SCHEMBL28123305 | 0.94 | CA4 (0.42) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| T-Butylacetic Acid SCHEMBL11218671 | 0.91 | — | — | |
| T-Butylacetic Acid SCHEMBL4319302 | 0.91 | — | — | |
| T-Butylacetic Acid SCHEMBL6500330 | 0.91 | — | — | |
| T-Butylacetic Acid SCHEMBL18258678 | 0.91 | CA4 (0.43) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| T-Butylacetic Acid SCHEMBL6098037 | 0.88 | CA4 (0.42) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| T-Butylacetic Acid SCHEMBL7859363 | 0.86 | CA4 (0.40) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| T-Butylacetic Acid SCHEMBL28494927 | 0.86 | CA4 (0.40) | CA4FFAR3HDAC3HDAC1HDAC2 | |
| T-Butylacetic Acid SCHEMBL6567111 | 0.81 | CA4 (0.42) | CA4FFAR3HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210206932-A1 | ACTIVATION METHOD USING MODIFYING AGENT | THE BOEING COMPANY | 2021-07-08 | — | — | US | disclosed |
| US-10888896-B2 | Activation method using modifying agent | THE BOEING COMPANY (US) | 2021-01-12 | — | — | US | disclosed |
| US-20180251643-A1 | ACTIVATION METHOD USING MODIFYING AGENT | THE BOEING COMPANY | 2018-09-06 | — | — | US | disclosed |
| EP-1828335-B1 | ACTIVATION METHOD USING MODIFYING AGENT | COMMW SCIENT IND RES ORG (AU) | 2010-03-10 | — | — | EP | disclosed |
| EP-1828335-A4 | ACTIVATION METHOD USING MODIFYING AGENT | COMMW SCIENT IND RES ORG (AU) | 2008-03-12 | — | — | EP | disclosed |
| US-20080050598-A1 | Activation method using modifying agent | THE BOEING COMPANY | 2008-02-28 | — | — | US | disclosed |
| EP-1828335-A1 | ACTIVATION METHOD USING MODIFYING AGENT | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006086828-A1 | ACTIVATION METHOD USING MODIFYING AGENT | COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) | 2006-08-24 | — | — | WO | disclosed |