SCHEMBL31595601

SCHEMBL31595601

CNC(=O)COc1cc2cc(Nc3nc(N4CCN(CC5CCN(c6cccc7c6C(=O)N(C6CCC(=O)NC6=O)C7=O)CC5)CC4)ncc3Cl)ccc2n(CCN(C)C)c1=O

nearest known ligand 0.46

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ BCL6 P41182 5/20 0.46
▸ NCOR2 Q9Y618 4/20 0.46
▸ MELK Q14680 1/20 0.45
▸ PTK2 Q05397 15/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23268203 1.00 BCL6 (0.46) BCL6NCOR2MELKPTK2
SCHEMBL23267971 0.94 PTK2 (0.47) BCL6NCOR2MELKPTK2
SCHEMBL31595473 0.94 PTK2 (0.47) BCL6NCOR2MELKPTK2
SCHEMBL31595238 0.94 BCL6 (0.47) BCL6NCOR2MELKPTK2
SCHEMBL23266802 0.94 BCL6 (0.47) BCL6NCOR2MELKPTK2
SCHEMBL23267332 0.93 BCL6 (0.46) BCL6NCOR2MELKPTK2
SCHEMBL31595225 0.93 BCL6 (0.46) BCL6NCOR2MELKPTK2
SCHEMBL23250042 0.93 BCL6 (0.54) BCL6NCOR2MELKPTK2
SCHEMBL23267348 0.93 BCL6 (0.54) BCL6NCOR2MELKPTK2
SCHEMBL31595669 0.93 BCL6 (0.54) BCL6NCOR2MELKPTK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12310975-B2 Modulators of BCL6 proteolysis and associated methods of use ARVINAS OPERATIONS, INC. (US) 2025-05-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12310975-B2 Modulators of BCL6 proteolysis and associated methods of use BCL6, BCL6B, BCL3 BCL6 1/4885NCOR2 640/4885MELK 446/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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