Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3169774 | 0.89 | ADORA2A (0.43) | ADORA1ADORA2AP2RY12KDM4EADORA3 | |
| SCHEMBL3163481 | 0.88 | ADORA2A (0.41) | CKS1BSKP1SKP2ADORA1ADORA2A | |
| SCHEMBL3162937 | 0.87 | ADORA2A (0.46) | ADORA1ADORA2AP2RY12KDM4EADORA3 | |
| SCHEMBL3165495 | 0.87 | TDP1 (0.45) | TDP1ADORA1ADORA2AKDM4EADORA3 | |
| SCHEMBL3174594 | 0.86 | ADORA2A (0.45) | ADORA1ADORA2AP2RY12KDM4EADORA3 | |
| SCHEMBL3175769 | 0.86 | ADORA2A (0.45) | ADORA1ADORA2AP2RY12KDM4EADORA3 | |
| SCHEMBL3166225 | 0.86 | ADORA2A (0.45) | ADORA1ADORA2AP2RY12KDM4EADORA3 | |
| SCHEMBL3171546 | 0.86 | ADORA2A (0.40) | POLBADORA1ADORA2AL3MBTL1ADORA3 | |
| SCHEMBL3172373 | 0.86 | GRIN2D (0.49) | NPSR1MEN1KMT2APOLBADORA1 | |
| SCHEMBL3155892 | 0.85 | ADORA2A (0.46) | ADORA1ADORA2AP2RY12KDM4EADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465631-B1 | PYRIMIDINE A2B SELECTIVE ANTAGONIST COMPOUNDS, THEIR SYNTHESIS AND USE | OSI PHARM INC (US) | 2010-02-24 | — | — | EP | disclosed |