Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31637028 | 0.84 | TSHR (0.36) | TSHR | |
| SCHEMBL25971101 | 0.82 | PDE4A (0.38) | HSD17B10 | |
| SCHEMBL31637066 | 0.78 | TSHR (0.34) | TSHRALOX15HRH3 | |
| SCHEMBL24837667 | 0.78 | TSHR (0.39) | TSHRALOX15HRH3MEN1KMT2A | |
| SCHEMBL22722883 | 0.76 | TSHR (0.38) | TSHRALOX15HRH3MEN1KMT2A | |
| SCHEMBL26614403 | 0.76 | TSHR (0.38) | TSHRALOX15HRH3MEN1KMT2A | |
| SCHEMBL10129066 | 0.76 | TSHR (0.38) | TSHRALOX15HRH3MEN1KMT2A | |
| SCHEMBL12717161 | 0.75 | TSHR (0.36) | TSHRHRH3 | |
| SCHEMBL10058645 | 0.75 | TSHR (0.36) | TSHRHRH3 | |
| Ammonia Solution, Strong SCHEMBL28870908 | 0.73 | TSHR (0.35) | TSHRHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250205344-A1 | 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERATIVES AS DEGRONS IN PROTACS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2025-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250205344-A1 | 2,4-DIOXOTETRAHYDROPYRIMIDINYL DERATIVES AS DEGRONS IN PROTACS | CRBN, AR, GNRHR | TSHR 1382/4885ALOX15 3737/4885HRH3 1904/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.