SCHEMBL31637597

SCHEMBL31637597

O=C1CCC(N2C(=O)c3cccc(NCCCCCOC4CCCNC4)c3C2=O)C(=O)N1

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 11/20 0.56
DDB1 Q16531 8/20 0.56
CA2 P00918 2/20 0.55
STAT3 P40763 5/20 0.54
HDAC3 O15379 3/20 0.52
HDAC1 Q13547 3/20 0.52
HDAC2 Q92769 3/20 0.52
NCOR2 Q9Y618 3/20 0.52
HDAC8 Q9BY41 1/20 0.49
TNF P01375 1/20 0.48
IL1B P01584 1/20 0.48
TBXA2R P21731 1/20 0.48
IKZF1 Q13422 1/20 0.48
IKZF3 Q9UKT9 1/20 0.48
CDK2 P24941 1/20 0.47
CDK9 P50750 1/20 0.47
CDK5 Q00535 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21997710 0.89 CRBN (0.61) CRBNDDB1CA2STAT3HDAC3
SCHEMBL21996796 0.87 CRBN (0.62) CRBNDDB1CA2STAT3HDAC3
SCHEMBL20932188 0.85 CRBN (0.75) CRBNDDB1CA2STAT3HDAC3
SCHEMBL21997784 0.84 CRBN (0.66) CRBNDDB1CA2STAT3HDAC1
SCHEMBL20887843 0.84 CRBN (0.65) CRBNDDB1CA2STAT3HDAC3
SCHEMBL31637746 0.83 CRBN (0.55) CRBNDDB1CA2STAT3HDAC3
SCHEMBL22849603 0.83 CRBN (0.64) CRBNDDB1CA2STAT3HDAC3
SCHEMBL23905114 0.83 CRBN (0.68) CRBNDDB1CA2STAT3HDAC3
SCHEMBL25237183 0.82 CRBN (0.62) CRBNDDB1CA2STAT3HDAC3
SCHEMBL29986699 0.82 CRBN (0.62) CRBNDDB1CA2STAT3HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025137613-A1 CYCLOALKYLENE NRF2 PROTEIN DEGRADERS GANYMEDE ONCOLOGY, INC. (US) 2025-06-26 WO disclosed