Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 20/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | FABP1 | P07148 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | LIFR | P42702 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3164111 | 1.00 | NR1H4 (0.79) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL10157975 | 0.95 | NR1H4 (0.88) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL498221 | 0.88 | NR1H4 (1.00) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL498222 | 0.88 | NR1H4 (1.00) | NR1H4MEN1FABP1THRBLIFR | |
| SCHEMBL3150227 | 0.84 | NR1H4 (0.59) | NR1H4LIFR | |
| SCHEMBL3150919 | 0.83 | NR1H4 (0.61) | NR1H4 | |
| SCHEMBL498760 | 0.83 | NR1H4 (0.58) | NR1H4 | |
| SCHEMBL3159473 | 0.82 | NR1H4 (0.63) | NR1H4 | |
| SCHEMBL3159467 | 0.82 | NR1H4 (0.63) | NR1H4 | |
| SCHEMBL498759 | 0.82 | NR1H4 (0.57) | NR1H4LIFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2029558-B1 | COMPOUNDS AND METHODS FOR MODULATING FXR | LILLY CO ELI (US) | 2010-03-10 | — | — | EP | disclosed |
| CN-101448798-A | Compounds and methods for modulating FXR | LILLY CO ELI (US) | 2009-06-03 | — | — | CN | disclosed |