SCHEMBL31642983

SCHEMBL31642983

O=C1NCC2(CCCN(c3nc(OC[C@@]45CCCN4C[C@H](F)C5)nc4c(F)c(Cl)ncc34)C2)O1

nearest known ligand 0.66

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ KRAS P01116 20/20 0.66

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31642466 1.00 KRAS (0.66) KRAS
SCHEMBL25051664 1.00 KRAS (0.66) KRAS
SCHEMBL31642667 0.88 KRAS (0.71) KRAS
SCHEMBL29341210 0.88 KRAS (0.71) KRAS
SCHEMBL25051844 0.88 KRAS (0.68) KRAS
SCHEMBL30134607 0.88 KRAS (0.68) KRAS
SCHEMBL29680887 0.86 KRAS (0.55) KRAS
SCHEMBL24535706 0.86 KRAS (0.54) KRAS
SCHEMBL29680268 0.86 KRAS (0.54) KRAS
SCHEMBL30922585 0.85 KRAS (0.61) KRAS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025136346-A1 INDAZOLE CONTAINING COMPOUNDS AND METHODS OF USE AMGEN INC. (US) 2025-06-26 — — WO disclosed
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