Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 16/20 | 0.83 |
| ▸ | PDE3A | Q14432 | 16/20 | 0.83 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847545 | 0.91 | PDE4B (1.00) | PDE4BPDE3A | |
| SCHEMBL2843550 | 0.85 | PDE4B (1.00) | PDE4BPDE3APSEN1PSEN2APH1B | |
| SCHEMBL2845130 | 0.84 | PDE4B (0.77) | PDE4BPDE3A | |
| SCHEMBL2852198 | 0.81 | PDE4B (0.68) | PDE4BPDE3A | |
| SCHEMBL3122129 | 0.78 | PDE4B (0.74) | PDE4BPDE3A | |
| SCHEMBL2842386 | 0.77 | PDE4B (0.76) | PDE4BPDE3A | |
| SCHEMBL2844159 | 0.76 | PDE4B (0.75) | PDE4BPDE3A | |
| SCHEMBL2851371 | 0.73 | PDE4B (0.70) | PDE4BPDE3A | |
| SCHEMBL2845455 | 0.72 | PDE4B (0.77) | PDE4BPDE3A | |
| SCHEMBL2844354 | 0.72 | PDE4B (0.68) | PDE4BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168960-A1 | PYRAZOLONE DERIVATIVE AND PDE INHIBITOR CONTAINING THE SAME AS ACTIVE INGREDIENT | Kyorin Pharmaceutical Co., Ltd. (JP) | 2010-03-31 | — | — | EP | disclosed |