Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nordefrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.50 |
| ▸ | ADRA2C known ✓ | P18825 | 2/20 | 0.50 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 1.00 |
| ▸ | TDP1 | Q9NUW8 | 8/20 | 0.96 |
| ▸ | RECQL | P46063 | 6/20 | 0.96 |
| ▸ | MAPT | P10636 | 5/20 | 0.96 |
| ▸ | LMNA | P02545 | 5/20 | 0.96 |
| ▸ | BLM | P54132 | 4/20 | 0.96 |
| ▸ | APEX1 | P27695 | 3/20 | 0.96 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.96 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.96 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.96 |
| ▸ | TSHR | P16473 | 1/20 | 0.96 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.96 |
| ▸ | THPO | P40225 | 1/20 | 0.96 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.96 |
| ▸ | POLB | P06746 | 1/20 | 0.96 |
| ▸ | MTOR | P42345 | 1/20 | 0.96 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nordefrin SCHEMBL5060952 | 1.00 | KDM4E (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Levonordefrin SCHEMBL363800 | 1.00 | KDM4E (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Levonordefrin SCHEMBL1780761 | 0.98 | TDP1 (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Levonordefrin SCHEMBL14478222 | 0.98 | TDP1 (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Levonordefrin SCHEMBL29410156 | 0.98 | TDP1 (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Levonordefrin SCHEMBL119171 | 0.98 | TDP1 (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Nordefrin SCHEMBL29693041 | 0.98 | TDP1 (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Levonordefrin SCHEMBL6295856 | 0.98 | TDP1 (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Nordefrin SCHEMBL249722 | 0.98 | TDP1 (1.00) | KDM4ETDP1RECQLMAPTLMNA | |
| Levonordefrin SCHEMBL14478226 | 0.98 | TDP1 (1.00) | KDM4ETDP1RECQLMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 104 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1294519-A | Pharmaceutical composition containing a compound having an activity of promoting the absorption of an active ingredient | INPHARMA SA (CH) | 2001-05-09 | — | — | CN | claimed |
| EP-1073470-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2001-02-07 | — | — | EP | claimed |
| WO-2000048636-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING COMPOUNDS WITH ACTIVITY FOR THE ENHANCEMENT OF ABSORPTION OF ACTIVE INGREDIENTS | INPHARMA S.A. (CH) | 2000-08-24 | — | — | WO | claimed |
| US-20200197310-A1 | Technology for Preparation of Macromolecular Microspheres | NEXBIO, INC. | 2020-06-25 | — | — | US | disclosed |
| US-10583086-B2 | Technology for preparation of macromolecular microspheres | ANSUN BIOPHARMA, INC. (US) | 2020-03-10 | — | — | US | disclosed |
| US-10231938-B2 | Transdermal drug delivery device including an occlusive backing | NOVEN PHARMACEUTICALS, INC. (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180071219-A1 | Technology for Preparation of Macromolecular Microspheres | NEXBIO, INC. | 2018-03-15 | — | — | US | disclosed |
| US-20180028449-A1 | Technology for the Preparation of Microparticles | NEXBIO, INC. | 2018-02-01 | — | — | US | disclosed |
| US-9682043-B2 | Method of preparation of mixed phase co-crystals with active agents | MEDCRYSTALFORMS, LLC (US) | 2017-06-20 | — | — | US | disclosed |
| US-20170079920-A1 | Technology for the Preparation of Microparticles | NEXBIO, INC. | 2017-03-23 | — | — | US | disclosed |
| US-20160235675-A1 | Technology for the Preparation of Microparticles | NEXBIO, INC. | 2016-08-18 | — | — | US | disclosed |
| EP-1021204-A2 | BIOADHESIVE COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF ACTIVE AGENTS | NOVEN PHARMACEUTICALS, INC. (US) | 2000-07-26 | — | — | EP | disclosed |
| US-6024976-A | TRANSDERMAL DRUG DELIVERY WITH PRESSURE SENSITIVE ADHESIVE COMPOSITION OF POLYVINYLPYRROLIDONE WITH DRUG IN MULTILAYER PATCH | NOVEN PHARMACEUTICALS, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| WO-1999015210-A2 | BIOADHESIVE COMPOSITIONS AND METHODS FOR TOPICAL ADMINISTRATION OF ACTIVE AGENTS | NOVEN PHARMACEUTICALS, INC. (US) | 1999-04-01 | — | — | WO | disclosed |
| US-5656286-A | BLEND OF TWO POLYMERS; PRESSURE SENSITIVE ADHESIVE | NOVEN PHARMACEUTICALS, INC. (US) | 1997-08-12 | — | — | US | disclosed |
| WO-1994000432-A1 | ANORECTIC EPINEPHRINE DERIVATIVES | THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 1994-01-06 | — | — | WO | disclosed |
| US-4590210-A | ALPHA-METHYL-EPINEPHRINE OR-NOREPINEPHRINE AND ALKANOYL ESTERS | DOBBIE, GRAHAM J. | 1986-05-20 | — | — | US | disclosed |
| EP-0067910-A1 | Compounds and compositions for treatment of ocular hypertension | Langham, Maurice E. (US) | 1982-12-29 | — | — | EP | disclosed |
| WO-1982003327-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATMENT OF OCULAR HYPERTENSION | LANGHAM MAURICE E | 1982-10-14 | — | — | WO | disclosed |
| US-4275074-A | Catecholamine treatment of ocular hypertension | Dobbie, Graham J. (US) | 1981-06-23 | — | — | US | disclosed |