SCHEMBL31655804

SCHEMBL31655804

Nc1ncnc2c1c(-c1cccc(O)c1)nn2Cc1nc2cccc(C#CCCCCC(=O)N3CCOCC3)c2c(=O)n1Cc1ccccc1Cl

nearest known ligand 0.86

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PIK3CD O00329 17/20 0.86
PIK3CG P48736 16/20 0.86
PIK3R1 P27986 7/20 0.86
PIK3CA P42336 5/20 0.72
PIK3CB P42338 4/20 0.72
ABL1 P00519 1/20 0.47
SRC P12931 1/20 0.47
MTOR P42345 1/20 0.47
PRKDC P78527 1/20 0.47
PIK3C2B O00750 1/20 0.43
KCNH2 Q12809 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11538 1.00 PIK3CD (0.86) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL31655785 0.98 PIK3CD (0.89) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL8616 0.98 PIK3CD (0.89) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL31655828 0.96 PIK3CG (0.83) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL11146 0.96 PIK3CG (0.83) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL31655817 0.93 PIK3CG (0.81) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL11669 0.93 PIK3CG (0.81) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL9623 0.93 PIK3CD (1.00) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL31655776 0.93 PIK3CD (1.00) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB
SCHEMBL11307 0.92 PIK3CD (0.80) PIK3CDPIK3CGPIK3R1PIK3CAPIK3CB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12350302-B2 Dosing regime and formulations for type B adenoviruses Akamis Bio Limited (GB) 2025-07-08 US disclosed