Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 4/20 | 0.33 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4284332 | 0.85 | GSK3B (0.35) | PDE2AACKR3ADORA2AADORA1KIT | |
| SCHEMBL8037163 | 0.73 | GSK3B (0.47) | KIT | |
| Hydrochloric Acid SCHEMBL4281336 | 0.73 | GSK3B (0.46) | KIT | |
| Hydrochloric Acid SCHEMBL4292984 | 0.71 | ADORA2A (0.34) | ADORA2AADORA1 | |
| SCHEMBL3166285 | 0.70 | — | — | |
| SCHEMBL8039872 | 0.64 | GSK3B (0.39) | — | |
| Hydrochloric Acid SCHEMBL4287764 | 0.64 | GSK3B (0.38) | — | |
| SCHEMBL2984544 | 0.61 | F2RL3 (0.43) | ADORA2AADORA1KMT2A | |
| SCHEMBL2935927 | 0.59 | GSK3B (0.45) | KIT | |
| SCHEMBL2246653 | 0.58 | GSK3B (0.34) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2229392-A1 | TRIAZOLOTRIAZINES AND TRIAZOLOPYRAZINES AND THEIR USE AS GSK3BETA INHIBITORS | Bayer Schering Pharma Aktiengesellschaft (DE) | 2010-09-22 | — | — | EP | disclosed |
| WO-2009074259-A1 | TRIAZOLOTRIAZINES AND TRIAZOLOPYRAZINES AND THE USE THEREOF | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2009-06-18 | — | — | WO | disclosed |