Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Resomelagon. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2D | O15399 | 3/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Resomelagon SCHEMBL12123977 | 0.93 | KMT2A (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Resomelagon SCHEMBL29214574 | 0.93 | KMT2A (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Resomelagon SCHEMBL30064288 | 0.93 | KMT2A (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Resomelagon SCHEMBL29214577 | 0.93 | KMT2A (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Resomelagon SCHEMBL30065234 | 0.93 | KMT2A (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Resomelagon SCHEMBL29214576 | 0.93 | KMT2A (0.45) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Resomelagon SCHEMBL31670337 | 0.92 | KMT2A (0.44) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Resomelagon SCHEMBL30064248 | 0.92 | KMT2A (0.44) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| Succinic Acid SCHEMBL30154485 | 0.86 | KMT2A (0.39) | KMT2AKDM4EL3MBTL1ALDH1A1MAPT | |
| Resomelagon SCHEMBL30084718 | 0.84 | NPC1 (0.44) | KMT2AALDH1A1MAPTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4359076-B1 | PHENYL PYRROLE AMINOGUANIDINE SALTS AND FORMULATIONS | SYNACT PHARMA APS (DK) | 2025-08-06 | — | — | EP | disclosed |