Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 5/20 | 0.62 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 3/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 4/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16117861 | 1.00 | KRAS (0.62) | KRASSHMT2GAASCDALK | |
| SCHEMBL15337927 | 0.92 | KRAS (0.52) | KRASGAASCDALKEGFR | |
| SCHEMBL16122631 | 0.90 | KRAS (0.76) | KRASSHMT2GAAEGFRERBB2 | |
| SCHEMBL16122668 | 0.88 | KRAS (0.60) | KRASSHMT2GAAEGFRERBB2 | |
| SCHEMBL22550951 | 0.87 | KRAS (0.66) | KRASSHMT2GAAALDH1A1LMNA | |
| SCHEMBL16122893 | 0.86 | KRAS (0.65) | KRASSHMT2GAAEGFRCYP3A4 | |
| SCHEMBL30642296 | 0.85 | KRAS (0.64) | KRASSHMT2GAASCDALK | |
| SCHEMBL16117871 | 0.85 | KRAS (0.64) | KRASSHMT2GAASCDALK | |
| SCHEMBL30642322 | 0.85 | KRAS (0.74) | KRASSCD | |
| SCHEMBL16122152 | 0.85 | KRAS (0.74) | KRASSCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50527-E1 | Covalent inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2025-08-12 | — | — | US | disclosed |